inverse relation between mxa gene expression and age in multiple sclerosis patients reveals a gender difference in response to interferon therapy

نویسندگان

mohammad taheri department of medical genetics, faculty of medicine, shahid beheshti university of medical sciences, tehran, iran

mohammadreza mirinezhad department of medical genetics, mashhad university of medical sciences, mashhad, iran

mir davood omrani department of medical genetics, faculty of medicine, shahid beheshti university of medical sciences, tehran, iran

elham sajjadi department of hematology, school of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran

چکیده

multiple sclerosis (ms) is an inflammatory, multifocal, immune-mediated disease of the central nervous system that women are at a higher risk to acquire than men. myxovirus resistance protein a (mxa) is used as a predictive marker of bioactivity of interferon-beta (ifn-β) therapy in ms patients. this study was undertaken in west of iran to investigate gender differences in the expression level of mxa in relapsing-remitting ms (rrms) patients receiving ifn-β therapy, compared with untreated normal individuals. the expression level of the mxa gene in rrms samples were compared to untreated normal individuals using the extracted rna from whole blood of 50 rrms patients (31 females and 19 males) and 50 normal controls (29 females and 21 males). all patients were hla-drb1*15 negative and responded to ifn-β with a normal vitamin d level. the level of mxa gene expression was measured by quantitative rt-pcr. the levels of gene expression were decreased in rrms patients compared with normal counterparts ( p =0.025). this decrease was significant in females ( p =0.009) compared to males ( p >0.05). the level of expression varied across different female age-groups with no significant difference in women younger than 30 years, but a significant decrease in expression in women between 30 to 40 years or above 40 years of age was seen. there was neither linear correlation between the mxa expression level and risk of expanded disability status scale of kurtzke (edss); nor were there any significant correlation between expression status of mxa and duration of the disease. in conclusion, the decrease in the level of mxa expression in ms patients treated with ifn-β when compared to normal individuals was significantly lower in females than males.  this demonstrated a gender bias in the response to ifn-β therapy that will need to be confirmed and further investigated in more detail.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Baseline MxA mRNA Expression Predicts Interferon Beta Response in Multiple Sclerosis Patients

BACKGROUND Myxovirus resistance protein A (MxA) is a molecule induced after interferon-beta injection, mostly used to evaluate its bioactivity. There is little available data on clinical utility of baseline MxA mRNA status. The objective of the study is to investigate whether baseline MxA mRNA expression can predict relapse and disease progression in multiple sclerosis patients treated with int...

متن کامل

Gene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis

Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS). Cluster of Differentiation 226 (CD226) is one of the risk factors for MS.  Objectives: The present study aimed to evaluate the gene expression of CD226, and its protein serum level in peripheral blood samples of MS patients and healthy individuals. Materials & ...

متن کامل

interferon-gamma gene polymorphism in iranian patients with multiple sclerosis

interferon- gamma (ifn- γ) is an important immune regulator and inflammatory cytokine which is implicated in the pathogenesis of multiple sclerosis (ms). a single nucleotide polymorphism, t to a, at position +874 in the first intron has previously been shown. this polymorphism is associated with ifn- γ production level. to study the effect of this polymorphism on susceptibility to multiple scle...

متن کامل

identifying the strategies persian efl learners use in reading an expository text in english and examining its relation to reading-proficiency and motivation: a think-aloud study

هدف اصلی از این مطالعه بررسی نوع و میزان استراتژی هایی بود که دانشجویان فارسی زبان رشته ی زبان انگلیسی در حین خواندن یک متن انگلیسی به کار گرفتند. این مطالعه همچنین به بررسی تفاوت های استراتژی های مورد استفاده بین دارندگان سطح بالا و پایین درک مطلب پرداخت. نوع همبستگی بین استراتژی به کار گرفته و درک مطلب از یک سو و استراتژی به کار گرفته و انگیزه از سوی دیگر نیز در این تحقیق مورد آزمایش قرار گرف...

15 صفحه اول

MxA mRNA Quantification and Disability Progression in Interferon Beta-Treated Multiple Sclerosis Patients

Even though anti-interferon beta (IFNβ) antibodies are the main determinants of IFNβ bioactivity loss and Myxovirus-resistance protein A (MxA) is the most established marker of IFNβ biological activity in IFNβ-treated multiple sclerosis patients, their usefulness in the routine clinical practice is still debated. Therefore, 118 multiple sclerosis patients naïve for treatment were enrolled for a...

متن کامل

foxp3 gene expression in multiple sclerosis patients pre- and post mesenchymal stem cell therapy

multiple sclerosis (ms) is an inflammatory demyelinating and neurodegenerative disorder of  the  central  nervous  system (cns), which mainly affects  young adults. activated t lymphocytes promote the neuro-inflammatory cascade of ms by secreting pro-inflammatory cytokines and play a significant role in its pathogenesis. t  lymphocytes may trigger the inflammation, which in turn leads to axonal...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of allergy, asthma and immunology

جلد ۱۶، شماره ۱، صفحات ۲۱-۲۷

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023